Spray Drying is an established processing technology for the pharmaceutical industry. By co-precipitating API with a polymer in a stable amorphous solid dispersion, spray-drying improves dissolution rates and enhances the bioavailability of poorly soluble compounds. Additionally, for high dose drugs, spray-drying enables reduced tablet size by improving compression properties of drug powders.

In a related technique drug and a polymer can be sprayed together onto a bead support to form an amorphous drug/polymer layer on the bead using fluid-bed coating techniques. This will provide solubility enhancement and particles that are easily formulated in a capsule format.

Spray Drying Benefits

  • Enhanced bioavailability of poorly soluble compounds
  • Provides a physically stable drug form that enables processing of the dispersion into solid dosage forms
  • Improved therapeutic efficacy, safety, tolerability and/or patient compliance
  • Lowering dosage costs
  • Extending product life cycle
  • Achieve higher drug loading
  • Preparation of directly compressible powder

Spray Drying Advantages

A widely used processing technology, spray-drying offers a number of advantages over conventional multi-step processes and particle reduction technologies:

  • Creation of an amorphous solid dispersion
  • Ability to tailor-make particle properties – from very fine particles to agglomerated powders
  • Fast and continuous process
  • Suitable for heat-sensitive products
  • Processing of aqueous and organic solvent systems
  • Predictable scale-up
  • Encapsulation – enabling taste masking or controlled release dosage forms
  • Improved solubility without physical milling

Spray Drying Expertise

At Formex, we combine our expertise in formulation and process development with our capabilities in spray-drying to overcome some of the most difficult product development challenges. From analytical characterization to pilot scale manufacturing, Formex offers a comprehensive package of spray-drying capabilities to move your compound from discovery to the clinic:

  • Analytical Characterization
  • Feasibility Studies
  • Formulation/Process Development and Optimization
  • Scale-up
  • cGMP Clinical Supply Manufacturing
  • Formex Spray-Drying Processing Equipment

Spray Drying Processing Equipment

  • Anhydro MicraSpray 35
  • Anhydro MicraSpray 150
  • BUCHI Mini Spray Dryer B-290
  • BUCHI Nano Spray Dryer B-90

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